Medicated Care

Medicated Care

• Investigation of the inhibitory mechanism of NSAIDs-induced small intestinal mucosal injury by acetaminophen　- Verification of the possibility of suppressing injury by controlling serotonin receptors -

  The 45th Annual Meeting of Japanese Association for the Study of Pain

  2023/12/08

  Keiko Seki

• Investigation of the inhibitory action mechanism of acetaminophen on NSAIDs-induced small intestinal mucosal injury

  The 109th General Meeting of the Japanese Society of Gastroenterology

  2023/04/06

  Ryuto Kimura

• Investigation of the inhibitory mechanism of NSAIDs-induced small intestinal mucosal damage by acetaminophen

  Ulcer Research Vol 50 28-34

  2023/08/10

  Masayoshi Kobayashi

• Examination of irritant factors affecting corneal epithelial repair and corneal epithelial repair effect of retinol palmitate

  The 143rd Annual Meeting of the Pharmaceutical Society of Japan

  2023/03/25

  Haruki Horiuchi

• Investigation of the inhibitory mechanism of NSAIDs-induced small intestinal mucosal injury by acetaminophen

  The 50th Meeting of the Japanese Society of Ulcer Research

  2023/02/03

  Masayoshi Kobayashi

• Examination of the inhibitory mechanism of NSAIDs-induced gastrointestinal mucosal damage by acetaminophen

  The 44th Annual Meeting of Japanese Association for the Study of Pain

  2022/12/2-12/3

  Keiko Seki

• Investigation of the action mechanism of acetaminophen on NSAIDs-induced small intestinal mucosal injury

  Ulcer Research Vol 49 10-15

  2022/10/25

  Keiko Seki

• Relationship between changes in the intestinal microbiome and the protective effect of acetaminophen against NSAIDs-induced small Intestinal mucosal damage

  Ulcer Research Vol 49 45-48

  2022/10/25

  Yuto Aita

• The effects of sucralfate on chronic stress-induced duodenal low-grade inflammation

  Jpn Pharmacol Ther 2022 50（6）1003 - 1011

  2022/6/20

  Mayumi Tsuri

• Japanese Sake Yeast Improves the Quality of Sleep

  Journal of the Brewing Society of Japan

  2022/4/1

  Tomomi Sano

• Relationship between NSAIDs-induced small intestinal mucosal injury and microbiome -Elucidation of the injury suppression mechanism by acetaminophen-

  The 108th General Meeting of the Japanese Society of Gastroenterology

  2022/4/21-4/23

  Yuto Aita

• Investigation of the inhibitory action mechanism of acetaminophen on NSAIDs-induced small intestinal mucosal injury

  The 108th General Meeting of the Japanese Society of Gastroenterology

  2022/4/21-4/23

  Keiko Seki

• Received the 49th Meeting of the Japanese Society of Ulcer Research (2022) Encouragement Award
  「Investigation of the action mechanism of acetaminophen on NSAIDs-induced small intestinal mucosal injury」

  The 49th Meeting of the Japanese Society of Ulcer Research Encouragement Award

  2022/2/11-2/13

  Keiko Seki

• Elucidation of the relationship between suppression of NSAIDs-induced small intestinal injury by acetaminophen and bacterial flora

  The 49th Meeting of the Japanese Society of Ulcer Research

  2022/2/11-2/13

  Yuto Aita

• Alteration in meibum lipid composition and subjective symptoms due to aging and meibomian gland dysfunction

  The Ocular Surface

  2021/10/16

  Tomo Suzuki ^a),^b),Koji Kitazawa ^a), Yuko Cho ^a),^b), Masataka Yoshida ^c), Takashi Okumura ^c), Atsushi Sato ^c), Shigeru Kinoshita ^d)

  a) Department of Ophthalmology, Kyoto Prefectural University of Medicine
  b) Department of Ophthalmology, Kyoto City Hospital Organization
  c) Research and Development Headquarters, Lion Corporation,
  d) Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine

• Comparison of drug delivery behavior to pain-related tissues by different routes of administration using loxoprofen sodium hydrate

  The 54th JPA Congress of Pharmacy and Pharmaceutical Science

  2021/9/19-9/20

  Yasushi Kudo

• Usefulness of acetaminophen in ibuprofen-induced small bowel injury

  (Journal of Japanese Society of Gastroenterology) Nihon Shokakibyo Gakkai Zasshi. 2021;118(9):840-850

  2021/9/10

  Miyu Kitahara, Yuki Sakamoto, Ryuto Kimura, Keiko Seki

• Improvement of Evaporative Dry Eye with Meibomian Gland Dysfunction in Model Mice by Treatment with Ophthalmic Solution Containing Mineral Oil

  Translational Vision Science & Technology  Volume 10(21); 2021 April

  2021/4/20

  Keisuke Watanabe ¹), Masataka Yoshida ¹), Takashi Okumura ¹), Takayuki Sassa ²), Akio Kihara ²), Akira Uchiyama ¹)

  1) Research and Development Headquarters, Lion Corporation, 2)Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences

• Inhibition mechanism of NSAIDs-induced small intestinal mucosal injury by acetaminophen

  The 107th General Meeting of the Japanese Society of Gastroenterology

  2021/4/15-4/17

  Keiko Seki

• Inhibition of Ibuprofen-Induced Small Intestinal Mucosal Injury by Acetaminophen in Relation to Bacterial Flora

  The 107th General Meeting of the Japanese Society of Gastroenterology

  2021/4/15-4/17

  Yuto Aita

• Comparison of the drug efficacy of OTC antipyretic analgesic ingredients using a mouse model of tension-type headache

  The 48th Congress of the Japanese Headache Society

  2020/11/7-11/8

  Yuki Ogawa

• Effects of Benzalkonium Chloride and Preservative-Free Composition on the Corneal Epithelium Cells

  Journal of Ocular Pharmacology and Therapeutics Vol. 36, No. 9 / Nov 2020

  2020/11/5

  Kyohei Kabashima ¹), Akira Murakami ²), Nobuyuki Ebihara ³)

  1) Lion Corporation Odawara Research Center, 2)Department of Ophthalmology, Juntendo University
  Graduate School of Medicine,3)Department of Ophthalmology, Juntendo University Urayasu Hospital,

• Creation of a rat model of functional dyspepsia with chronic downregulation of tight junction component proteins

  Ulcer Research Vol 47 97-99

  2020/7/20

  Mayumi Tsuri、Takuya Hayakawa

• Mechanism of aspirin-induced inhibition on the secondary hyperalgesia in osteoarthritis model rats

  Heliyon, Volume 6, Issue 5, May 2020

  2020/5/24

  Mizuho Niibori ¹),Yasushi Kudo ¹),Takuya Hayakawa ¹), Keiko Ikoma-Seki Ryosuke Kawamata ¹), Atsushi Sato ¹), Kazue Mizumura ²),³)

  1)Research & Development Headquarters, Lion Corporation,
  2) Department of Physiology, Nihon University School of Dentistry,
  3) College of Life and Health Sciences, Chubu University,

• The Effect of Nonpolar Lipids in Meibum on Stability of Tear Film Lipid Layer against Compression-Expansion Cycles

  J. Oleo Sci. 69, (5) 429-436 (2020)

  2020/2/4

  Masataka Yoshida ¹), Masato Yamaguchi ²) Atsushi Sato ¹) , Miyuki Miyake ¹) , Nobuhito Tabuchi ¹) , Ryo Kon ¹) , and Ken-ichi Iimura ³)

  1) Research and Development Headquarters, Lion Corporation, 2)Department of Material and Environmental Chemistry, Graduate School of Engineering, Utsunomiya University, 3) Division of Engineering and Agriculture, Graduate School of Regional Development and Creativity, Utsunomiya University,

• Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats

  PLOS ONE 2019; 14(11): e0224809.

  2019/11/6

  Tetsuhiro Shimodaira ¹, Shigeo Mikoshiba ¹, Toru Taguchi ^{2 3}

  1)Lion Corporation, 2)Department of Physical Therapy, Niigata University of Health and Welfare, 3)Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare,

• The Analgesic Effect of Aspirin on Inflammatory Pain in Rats Is Affected by Pain Intensity and Administration Timing

  YAKUGAKU ZASSI (Journal of the Pharmaceutical Society of Japan) 140 (1) 91-97, 2020

  2019/10/25

  Miu Kitahara,Keiko Seki, Tatsuyuki Midorikawa, Junya Arita, and Akira Uchiyama
  Research & Development Headquarters, Lion Corporation,

• A thin layer of sucrose octasulfate protects esophageal mucosal epithelium against reflux esophagitis

  AAPS 2018 PHarmSCi 360

  2018/11/4-11/7

  Takuya Hayakawa

• Acetylsalicylic acid and conventional NSAIDs ameliorate muscular mechanical hyperalgesia through mechanisms other than COX-2 inhibition

  IASP 2018 World Congress on Pain

  2018/9/12-9/16

  Tetsuhiro Shimodaira

• Acetylsalicylic acid and loxoprofen ameliorate secondary hyperalgesia through mechanisms other than COX-2 inhibition in a rat model of osteoarthritis

  IASP 2018 World Congress on Pain

  2018/9/12-9/16

  Yasushi Kudo

• Influence of Non-Polar Lipids and Polar Lipids on Tear Film Lipid Layer Stability

  The 69th Divisional Meeting of Division of Colloid and Surface Chemistry

  2018/9/18-9/20

  Masataka Yoshida

• Vitamin A and Ery Eye

  Food and Medicine

  2018/9/1

  Nobuhito Tabuchi

• Mechanism of aspirin-induced inhibition on the secondary hyperalgesia in a rat osteoarthritis model —Effects of aspirin on ASIC3 expression and glial cells—

  The 40th Annual Meeting of Japanese Association for the Study of Pain

  2018/6/15-6/16

  Mizuho Niibori

• Relationship between Meibum Composition and Eye Fatigue in Meibomian Gland Dysfunction Patients

  The 123rd Annual Meeting of the Japanese Ophthalmological Society

  2018/4/18-4/21

  Masataka Yoshida

• Changes in Meibum Composition with Aging and Meibomian Gland Dysfunction

  The 123rd Annual Meeting of the Japanese Ophthalmological Society

  2018/4/18-4/21

  Masataka Yoshida

• Influence of Saturated Non-Polar Lipids on Tear Film Lipid Layer Stability

  The 98th CSJ Annual Meeting (2018）

  2018/3/20-3/23

  Masataka Yoshida

• Structural Analysis of Tear Film Lipid Layer in Compression-Expansion Cycles

  The 98th CSJ Annual Meeting (2018）

  2018/3/20-3/23

  Masataka Yoshida

• Hot Topics Award at Annual Meeting of Japan Society for Bioscienece 2018 , Biotechnology, and Agrochemistory
  「Establishment of a new in vitro exercise model and its application to analyze the mechanism of beta-hydroxy-beta-methylbutylate (HMB) on the contraction-induced protein synthesis」

  The 2018 Annual Meeting of the Japan Society for Bioscience, Biotechnology and Agrochemistry

  2018/3/16

  ○Satoko Sato ¹)、Yusuke Takamura ¹)、Ikkou Yamana ¹)、Mitsuru Nomura ¹)、Akira Uchiyama ¹)、Yasuro Furuichi ²)Yasuko Manabe ²)、Nobuharu Fujii ²)

  1)Research & Development Headquarters, LION Corporation, 2)Graduate School of Human Health Sciences, Tokyo Metropolitan University

• Comparison of effects of antacids on NSAIDs-induced gastric damages

  Ulcer Research Vol 45 85-89

  2018

  Kudo Yasushi

• Foundation, Oil and Fat Industury Kaikan, 62th Excellent article award in Oil and Fat technology
  「Membrane Permeation of Giant Unilamellar Vesicles and Corneal Epithelial Cells with Lipophilic Vitamin Nanoemulsions」

  Oil & Fat Industry Kaikan Award

  Miyuki Miyake ¹), Masatoshi Kurioka ¹), Masahiro Takagi ²)

  1)Lion Corporation,2)Japan Advanced Institute of Science and Technology