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Lion takes its responsibility for providing customers with peace of mind through safety evaluations based on scientific evidence extremely seriously. We conduct wide-ranging safety assessments of the effects of Lion products and their raw materials on people and the environment, applying technologies related to living organisms, including those in the fields of molecular biology and physiology. These assessments ensure that customers can use Lion products with confidence. In addition to performing evaluations, Lion is involved in the development of safety assessment technologies, such as alternatives to animal testing.
The importance of safety evaluation and confirmation is the same worldwide. Lion takes a global perspective as it aggressively gathers and analyzes safety data from in and outside Japan and uses such data in actual safety evaluations. At the same time, Lion actively participates in various industry associations, cooperating to help solve problems.
Alternative Approaches to Animal Testing
Evaluating Biodegradability and Environmental Impact—Fulfilling Our Social Responsibility to the Environment
Ring study of ADRA, in chemco alternative test method for skin sensitization, aimed at revised guideline
The 35th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2022/11/18-11/20
Hiroaki Yamaga,Shinichi Watanabe
Verification of Amino acid Derivative Reactivity Assay-Organic Solvent (ADRA-OS): Evaluation of Epoxides and Surfactants
ICT 2022 – XVIth International Congress of Toxicology
2022/9/18-9/21
Ryo Koizumi
Development of an Alternative Oral Mucosal Irritation Test Using a Three-dimensional Human Buccal Oral Mucosal Model -Analysis of Mechanisms of Toxicity in Mucosal Cells-
The 49th Annual Meeting of the Japanese Society of Toxicology
2022/6/30-7/2
Seiya Aizawa
Within- and between-laboratory reproducibility and predictive capacity of amino acid derivative reactivity assay (ADRA) using a 0.5 mg/mL test chemical solution: Results of the study for reproducibility confirmation implemented in five participating laboratories.
Journal of Applied Toxicology volume42, Issue 6 1078-1090 Jun 2022
2022/1/18
Yusuke Yamamoto 1), Masaharu Fujita 1) , , Shinichi Watanabe 2),Hiroaki Yamaga 2), Koji Wakabayashi 3), Yu Tahara 3), Nobuyuki Horie 4), Keiichi Fujimoto 4), Kazuya Takeuchi 5), Kohei Kamiya 5), Tsuyoshi Kawakami 6), Kohichi Kojima 7), Takashi Sozu 8), Hajime Kojima 9), Toshihiko Kasahara 1), Atsushi Ono 10)
1) Safety Evaluation Center, Fujifilm Corporation,2) Lion Corporation,
3)Chemical Safety Department, Mitsui Chemicals, Inc., 4) Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 5) Biological Research Laboratories, Nissan Chemical Corporation, 6)Division of Environmental Chemistry, National Institute of Health Sciences, 7) Food and Drug Safety Center, 8) Faculty of Engineering, Tokyo University of Science, 9) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 10) Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Sciences, Okayama University,
The within- and between-laboratories reproducibility and predictive capacity of Amino acid Derivative Reactivity Assay using 4 mM test chemical solution: Results of ring study implemented at five participating laboratories.
Journal of Applied Toxicology volume42, Issue 2 318-333 Feb 2022
2021/12/1
Masaharu Fujita 1), Yusuke Yamamoto 1), Sayaka Wanibuchi 1), Shinichi Watanabe 2), Hiroaki Yamaga 2), Koji Wakabayashi 3), Yu Tahara 3), Nobuyuki Horie 4), Keiichi Fujimoto 4), Kazuya Takeuchi 5), Kohei Kamiya 5), Tsuyoshi Kawakami 6), Kohichi Kojima 7), Takashi Sozu 8), Hajime Kojima 9), Toshihiko Kasahara 1), Atsushi Ono 10)
1) Safety Evaluation Center, Fujifilm Corporation,2) Lion Corporation, 3)Chemical Safety Department, Mitsui Chemicals, Inc., 4) Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 5) Biological Research Laboratories, Nissan Chemical Corporation, 6)Division of Environmental Chemistry, National Institute of Health Sciences, 7) Food and Drug Safety Center, 8) Faculty of Engineering, Tokyo University of Science, 9) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 10) Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Sciences, Okayama University,
Development of a new alternative skin sensitization test for the evaluation of highly hydrophobic substances：Amino acid Reactivity Assay-Organic Solvent (ADRA-OS) reaction system
The 34th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2021/11/11-11/13
Hiroaki Yamaga （Joint research with Fujifilm）
Validation Study of Epidermal Sensitization Assay (EpiSensA), an Alternative Method for Skin Sensitization Testing
The 34th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2021/11/11-11/13
Junko Ueno
The Japanese Society for Alternatives to Animal Experiments Best Presentation Award
A study of oral mucosal irritation testing with a reconstructed human gingival mucosal model
The 34th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2021/11/11-11/13
Joint research with Kao Corporation and Sunstar Corporation
A study of oral mucosal irritation testing with a reconstructed human gingival mucosal model
The 34th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2021/11/11-11/13
Joint research with Kao Corporation and Sunstar Corporation
The Japanese Society of Toxicology Excellent Research Presentation Award
Development of an Alternative Method for Oral Mucosal Irritation Testing Using a Human 3D Cultured Oral Mucosa Model -Validation of Criteria for Classification of Irritation/No Irritation
The 48th Annual Meeting of the Japanese Society of Toxicology
2021/7/7-7/9
Seiya Aizawa（Joint research with Kao Corporation and Sunstar Corporation）
Amino acid derivative reactivity assay-organic solvent reaction system: A novel alternative test for skin sensitization capable of assessing highly hydrophobic substances
Journal of Applied Toxicology volume41, Issue 10 1634-1648 Oct 2021
2021/2/26
Hiroaki Yamaga 1),Shinichi Watanabe 1),Masaharu Fujita 2),Yusuke Yamamoto 2),Toshihiko Kasahara 2),Shinsuke Kataoka 1)
1)Safety Science Research Laboratories, Lion Corporation
2)Safety Evaluation Center, Fujifilm Corporation
Introduction of EpiSensA, an alternative method for skin sensitization test using 3D human epidermis model, for evaluation of poorly water-soluble substances
The 33rd Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2020/11/12-11/13
Junko Ueno
The Japanese Society for Alternatives to Animal Experiments President's Special Award
A study of oral mucosal irritation testing with a reconstructed human gingival mucosal model
The 33rd Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2020/11/12-11/13
Joint research with Kao Corporation and Sunstar Corporation
The Japanese Society for Alternatives to Animal Experiments
Validation study of the Epidermal Sensitization Assay (EpiSensA), an alternative method for skin sensitization testing (Phase I of institutional reproducibility)
The 33rd Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2020/11/12-11/13
Joint research with Kao Corporation, KOSE Corporation and Food and Drugs Safety Center
Case studies of microbial problems in the manufacturing genba of cosmetics and personal care products
FRAGRANCE JOURNAL 2020/May No.479（Vol.48/No.5）
2020/5/1
Masahiko Otani
New approach to evaluation and classification of irritation intensity of oral care ingredients using a three-dimensional human buccal mucosal model.
Society of Toxicology 59th Annual Meeting
2020/3/15-19
Joint research with Kao Corporation and Sunstar Corporation
Oxidation of a cysteine-derived nucleophilic reagent by dimethyl sulfoxide in the amino acid derivative reactivity assay
Journal of Applied Toxicology volume40, Issue 6 843-854 Jun 2020
2020/2/12
Miyuki Akimoto 1), Yusuke Yamamoto 1), Shinichi Watanabe 2), Hiroaki Yamaga 2), Kousuke Yoshida 2), Koji Wakabayashi 3), Yu Tahara 3), Nobuyuki Horie 4), Keiichi Fujimoto 4), | Kei Kusakari 5), Kohei Kamiya 5), Kohichi Kojima 6), Tsuyoshi Kawakami 7), Hajime Kojima 8), Atsushi Ono 9), Toshihiko Kasahara 1), Masaharu Fujita 1)
1)Fujifilm Corporation, Safety Evaluation Center, 2)Lion Corporation, 3)Mitsui Chemicals, Inc. Chemical Safety Department, 4)Sumitomo Chemical Co. Ltd. Environmental Health Science Laboratory, 5)Nissan Chemical Corporation, Biological Research Laboratories, 6)Food and Drug Safety Center, Hatano Research Institute, 7)Division of Environmental Chemistry, National Institute of Health Sciences, 8)Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 9)Okayama University
Study of the pharmacokinetics of eriodictyol-6-C-β-d-glucoside, a flavonoid of rooibos (Aspalathus linearis) extract, after its oral administration in mice
Journal of Chromatography B , Volume1137, 15 January 2020, 121881
2020/1/15
Kanako Yuyama 1), Yoshitaka Nakamura a), Riho Tateyama a), Rieko Arakaki b), Takuya Tsutsui a), Naozumi Ishimaru b),
a)Research & Development Headquarters, Lion Corporation, b)Department of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences,
The within- and between-laboratory reproducibility and predictive capacity of the in chemico amino acid derivative reactivity assay: Results of validation study implemented in four participating laboratories
Journal of Applied Toxicology volume39, Issue 11 1492-1505 Nov 2019
2019/7/17
Masaharu Fujita 1), Yusuke Yamamoto 1), Shinichi Watanabe 2), Tsunetsugu Sugawara 2), Koji Wakabayashi 3), Yu Tahara 3), Nobuyuki Horie 4), Keiichi Fujimoto 4), Kei Kusakari 5), Yoshihiko Kurokawa 5), Tsuyoshi Kawakami 6), Kohichi Kojima 7), Takashi Sozu 8), Takuto Nakayama 8),Takeru Kusao 8), Jon Richmond 9), Kleinstreuer Nicole 10), Bae-Hwa Kim 11), Hajime Kojima 12), Toshihiko Kasahara 1), Atsushi Ono 13)
1) Safety Evaluation Center, Fujifilm Corporation, 2) Lion Corporation, 3) Chemical Safety Department, Mitsui Chemicals, Inc, 4) Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd, 5) Biological Research Laboratories, Nissan Chemical Corporation, 6) Division of Environmental Chemistry, National Institute of Health Sciences, 7) Food and Drug Safety Center, 8) Faculty of Engineering, Tokyo University of Science, 9) Dr. Jon Richmond: Advice and Consultancy,10) NTP Interagency Center for the Evaluation of Alternative Toxicological Methods, 11)College of Natural Sciences Keimyung University,12) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 13) Graduate School of Medicine, Dentistry and Pharmaceutical sciences, Division of Pharmaceutical Sciences, Okayama University,
Development of an Alternative Oral Mucosal Irritation Test Using a Three-dimensional Human
Buccal Mucosal Model － Study on Setting of Oral Mucosal Irritation Evaluation Flow for Raw
Materials and Products for Oral Care －
The 32nd Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2019/6/26-6/28
Seiya Aizawa
Development of ADRA-OS（Organic solvent reaction System）for poorly water-soluble sensitizers
The 32nd Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2019/6/26-6/28
Hiroaki Yamaga
The Study of Utility of a Three-dimensional Human Buccal Mucosal Model for Oral Mucosal Irritation Prediction of Raw Materials for Oral Care Supplies by the Three Facilities
The 31st Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2018/11/23-11/25
Seiya Aizawa
Current state and Issues of utilization of animal experiment alternative methods in safety evaluation by chemical industry
The 31st Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2018/11/23-11/25
Shinichi Watanabe
Cause of and countermeasures for oxidation of the cysteine-derived reagent used in the amino acid derivative reactivity assay
Journal of Applied Toxicology volume39, Issue 2 191-208 Feb 2019
2018/9/16
Masaharu Fujita 1), Yusuke Yamamoto 1), Shinichi Watanabe 2), Tsunetsugu Sugawara 2), Koji Wakabayashi 3), Yu Tahara 3), Nobuyuki Horie 4), Keiichi Fujimoto 4), Kei Kusakari 5), Yoshihiko Kurokawa 5), Tsuyoshi Kawakami 6), Kohichi Kojima 7), Hajime Kojima 8), Atsushi Ono 9), Yasuhiro Katsuoka 1), Hideto Tanabe 10), Hiroshi Yokoyama 10), Toshihiko Kasahara 1)
1) Safety Evaluation Center, Fujifilm Corporation, 2) Lion Corporation, 3) Mitsui Chemicals, Inc., Chemical Safety Department 4) Sumitomo Chemical Co., Ltd., Environmental Health Science Laboratory, 5) Nissan Chemical Corporation, Biological Research Laboratories, 6) National Institute of Health Sciences, Division of Environmental Chemistry,7) Food and Drug Safety Center, Hatano Research Institute, 8) National Institute of Health Sciences, Biological Safety Research Center, Division of Risk Assessment, 9) Okayama University, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Division of Pharmaceutical Sciences,10) Fujifilm Corporation, Research & Development Management Headquarters, Analysis Technology Center
A Study of Utility of a Three-dimensional Human Buccal Mucosal Model and Gingival Model for Oral Mucosal Irritation Evaluation
The 45th Annual Meeting of the Japanese Society of Toxicology
2018/7/18-7/20
Seiya Aizawa